MAGNESIUM DEMIS (MAGNESIUM B6) is gluten-free. Lactose-free
Active ingredients 3 tablets each
Magnesium (from Magnesium Carbonate, Magnesium Bisglycinate Chelate, Magnesium Citrate, Sucrosomial® Marine Agnes, Magnesium L-Pidolate) – 420 mg (112% NRV)
Vitamin B6 (pyridoxine hydrochloride) – 4.2 mg (300% NRV)
*NRV: Nutrient Reference Value, link.
Regulation (EC). No. 1169/2011.
Other ingredients:
Magnesium bisglycinate chelate excipients: citric acid, maltodextrin, anti-caking agent: silicon dioxide.
Excipients Sucrosomial marine Magnesium (Sidemeg): corn starch, emulsifiers: esters of sucrose and fatty acids, sunflower lecithin.
Fillers: cellulose, dicalcium phosphate; corn starch; anti-caking agents; magnesium salts of fatty acids (vegetable), silicon dioxide.
Pharmacological action
Pills. MagDemis is based on marine magnesium Sucrosomial and four other sources of magnesium with a high degree of digestibility, enriched with vitamins B6. Magnesium is a vital element that is found in all tissues of the body and is necessary for the normal functioning of cells, participates in most metabolic reactions. In particular, it participates in the regulation of the transmission of nerve impulses and in muscle contraction. The body receives magnesium along with food. A lack of magnesium in the body can be observed with a violation of the diet (diet), with an increase in the need for magnesium, or with an imbalance in the intake, metabolism and excretion of magnesium (for example, with increased physical and mental stress, stress, during pregnancy, when using diuretics).
VITAMIN B6 – Vitamin B6 supplements are designed to improve the absorption of magnesium (a very important aspect in case of suspected deficiency or subdeficiency). Vitamin B6 works synergistically with magnesium, stimulating the immune system, preventing certain disorders of the nervous system, controlling diabetes and counteracting metabolic imbalances resulting from hormonal changes, especially those associated with the premenstrual period. It is necessary for the metabolism of nucleic acids and proteins, guaranteeing the effectiveness of more than 60 enzymes, its supplement provides energy and tone to our body and counteracts physical and mental fatigue.
Pharmacokinetics
Absorption and distribution
Absorption of magnesium from the gastrointestinal tract is no more than 50% of the dose taken orally. In the body, magnesium is distributed mainly in the intracellular space – about 99%, of which about 2/3 is distributed in bone tissue, 1/3 is in smooth and striated muscle tissue.
Withdrawal
Magnesium is excreted mainly in the urine (at least 1/3 of the dose of magnesium taken).
Preclinical safety data
In preclinical data obtained from the results of standard studies of pharmacological safety, repeated administration toxicity, genotoxicity, carcinogenic potential and reproductive and ontological toxicity, no special harm to humans has been identified.
Indications of the drug MagDemis (magnesium B6)
An established magnesium deficiency, isolated or associated with other deficiency conditions, accompanied by symptoms such as:
Use during pregnancy and lactation
Pregnancy
Clinical experience of using the drug in a sufficient number of pregnant women has not revealed any adverse effect on the occurrence of fetal malformations or fetotoxic effects.
The drug MagDemis can be used during pregnancy only if necessary and on the recommendation of a doctor.
Breastfeeding period
Magnesium penetrates into breast milk. The use of the drug during breastfeeding should be avoided.
Use in children
It is contraindicated in children under 6 years of age.
Dosage
It is recommended to take 2-3 tablets a day.
Contraindications to use
Packaging
60 tablets of 1g each in a pill bottle.
MANUFACTURER: “ERBA VITA” Group SpA, Republic of San Marino
DISTRIBUTOR: DEMI FARM LLC www.demipharm.am